Siamese pyramidal deep learning network for strain estimation in 3D cardiac cine-MR.

Strain represents the quantification of regional tissue deformation within a given area. Myocardial strain has demonstrated considerable utility as an indicator for the assessment of cardiac function. Notably, it exhibits greater sensitivity in detecting subtle myocardial abnormalities compared to conventional cardiac function indices, like left ventricle ejection fraction (LVEF). Nonetheless, the estimation of strain poses considerable challenges due to the necessity for precise tracking of myocardial motion throughout the complete cardiac cycle. This study introduces a novel deep learning-based pipeline, designed to automatically and accurately estimate myocardial strain from three-dimensional (3D) cine-MR images. Consequently, our investigation presents a comprehensive pipeline for the precise quantification of local and global myocardial strain. This pipeline incorporates a supervised Convolutional Neural Network (CNN) for accurate segmentation of the cardiac muscle and an unsupervised CNN for robust left ventricle motion tracking, enabling the estimation of strain in both artificial phantoms and real cine-MR images. Our investigation involved a comprehensive comparison of our findings with those obtained from two commonly utilized commercial software in this field. This analysis encompassed the examination of both intra- and inter-user variability. The proposed pipeline exhibited demonstrable reliability and reduced divergence levels when compared to alternative systems. Additionally, our approach is entirely independent of previous user data, effectively eliminating any potential user bias that could influence the strain analyses.

Automatic myocardium strain quantification in MR synthetic images with Deep Leaning.

Accurate quantification of myocardium strain in magnetic resonance images is important to correctly diagnose and monitor cardiac diseases. Currently, available methods to estimate motion are based on tracking brightness pattern differences between images. In cine-MR images, the myocardium interior presents an inhered homogeneity, which reduces the accuracy in estimated motion, and consequently strain. Neural networks have recently been shown to be an important tool for a variety of applications, including motion estimation. In this work, we investigate the feasibility of quantifying myocardium strain in cardiac resonance synthetic images using motion generated by a compact and powerful network called Pyramid, Warping, and Cost Volume (PWC). Using the motion generated by the neural network, the radial myocardium strain obtained presents a mean average error of 12.30% +- 6.50%, and in the circumferential direction 1.20% +-0.61 %, better than the two classical methods evaluated. Clinical Relevance- This work demonstrates the feasibility of estimating myocardium strain using motion estimated by a convolutional neural network.